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Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin
Ronit Satchi-Fainaro1, Roni Mamluk1, Ling Wang3, Sarah M. Short1, Janice A. Nagy2, Dian Feng2, Ann M. Dvorak2, Harold F. Dvorak2, Mark Puder1, Debabrata Mukhopadhyay2, 3 and Judah Folkman1, ,
1Children’s Hospital Boston and Harvard Medical School, Vascular Biology Program, Department of Surgery, 1 Blackfan Circle, Karp Family Research Laboratories, Floor 12, Boston, Massachusetts 02115
2Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215
3Biochemistry and Molecular Biology and Mayo Cancer Center, Mayo Clinic, Rochester, Minnesota 55905
Received 9 February 2004; revised 16 September 2004; accepted 15 February 2005. Published: March 14, 2005. Available online 14 March 2005.
Summary
Angiogenesis inhibitors, such as TNP-470 and the nontoxic HPMA copolymer-TNP-470 (caplostatin), are emerging as a class of anticancer drugs. We report that TNP-470 and caplostatin inhibit vascular hyperpermeability of tumor blood vessels as well as that induced in mouse skin by different mediators. Treatment with TNP-470 or angiostatin for 3 days was sufficient to reduce permeability of tumor blood vessels, delayed-type hypersensitivity, and pulmonary edema induced by IL-2. TNP-470 also inhibited VPF/VEGF-induced phosphorylation of VEGFR-2, calcium influx, and RhoA activation in endothelial cells. These results identify an activity of TNP-470, that of inhibiting vessel hyperpermeability. This activity likely contributes to TNP-470’s antiangiogenic effect and suggests that caplostatin can be used in the treatment of cancer and inflammation.
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Questo è un altro articolo grazie al quale si può dedurre che la strada che si sta seguendo è promettente. bloccare il rifornimento di "nutrimenti" alle cellule tumorali tramite farmaci mirati che agiscono sui vasi sanguigni.
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Foster83.
User deleted
Mi sembra giusto che anzichè distruggerle che non è così facile, si faccia modo che muoiano "d'inedia". 
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Inhibition of vessel permeability by TNP-470 |
